History question with answer

Q.With reference to the scientific progress of ancient India, which of the statements given below are correct? 1. Different kinds of specialised surgical instruments were in common use by A.D. first century. 2. Transplant of internal organs in the human body had begun by the beginning of A.D. third century. 3. The concept of the sine of an angle was known in A.D. fifth century. 4. The concept of cyclic quadrilaterals was known in A.D. seventh century. Select the correct answer using the code given below.